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    articletype= Research Article,
    title = {Title\\ {\footnotesize[The title of the manuscript should be concise, specific, and relevant. It should clearly state the main result or conclusion of the manuscript, omitting implicit terms and avoiding abbreviations.]}},
    author = {Forename Surname, 1, Forename Surname, 1, Forename Surname, {2,*}, Forename Surname, {3}, Forename Surname, {1}},
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    	\textsuperscript{1}Department, University, City Postcode, Province, Country.\\
    	\textsuperscript{2}Department, Institution, City, State Postcode, Country.\\
    	\textsuperscript{3}Department, University, City Postcode, Country.
    	%        \textsuperscript{\#}Authors contributed equally.
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    correspond = {Forename Surname, Department, Institution, City, State Postcode, Country. E-mail: \url{xxxxxx}},
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        First Author, Second Author, Third Author. The title of the cited article. Journal Abbreviation. 2025;1:Manuscript ID. \url{DOI}
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\begin{document}

\linespread{1.2}
\maketitle

\begin{abstract}
  \textit{[Suggestions: No more than 250 words. No citations. Define abbreviations at their first mention.]}
  
  Research articles require structured abstracts that briefly introduce the research area and problem, state the study's aims, summarize the design, methods, and analyses, present key findings with essential data, and conclude with the main implications and significance.
  
  
  \keywords{Keyword 1, keyword 2, keyword 3}
  
  \textit{[Typically, 3-8 keywords should be provided which can be used for describing the content of the manuscript and will enable the full text of the manuscript to be searchable online.]}
\end{abstract}

\section{Introduction}

The Introduction section should succinctly introduce the study's background and rationale, highlight the research question or objective, summarize relevant literature, and outline the study's aims and scope. It sets the context for the study and justifies its importance in the field. Avoid including any data or conclusions from the study being reported.

\section{Methods}

The Methods section should clearly describe the study design, participants, interventions or exposures, outcome measures, data collection procedures, and statistical analyses. Details such as study type, participant characteristics, instruments used, and analytical methods should be included to ensure clarity, reproducibility, and scientific rigor.

\subsection{Level 2 heading}

\subsubsection{Level 3 heading}

\textit{Tips:}
\begin{itemize}
	\item \textit{Include ethical approval and informed consent details, specifying the approving committee or IRB and compliance with guidelines.}
	\item \textit{Describe how informed consent was obtained from participants or their representatives.}
	\item \textit{For studies using AI, detail its use to allow replication, including the tool, version, and prompts if applicable.}
\end{itemize}

\section{Results}

The Results section should clearly present study findings, summarizing participant characteristics if applicable and reporting key outcomes with appropriate statistical measures.

\textit{Tips:}
\begin{itemize}
	\item \textit{Use tables, figures, and graphs to present data and highlight key findings.}
	\item \textit{Do not repeat all table or figure data in the text.}
	\item \textit{Avoid ambiguous or nontechnical statistical terms.}
	\item \textit{Report results objectively without interpretation.}
	\item \textit{Include supplementary materials or technical details in an appendix or electronic version.}
\end{itemize}

\textbf{Table 1} (other forms: Table 1 and Table 2), \textbf{Figure 1} (other forms: Figure 1A,B; Figure 2a,b,c; Figure 1 and Figure 2A) and \textbf{Equation (1)} [other forms: Equation (2) and Equation (3)] show the examples of diagrams. All the tables, figures and equations should be cited in sequence in the main content near to the first time they appear. For supplementary material, authors may cite table, equation and figure like \textbf{Table S1}, \textbf{Figure S1} and \textbf{Equation S(1)}.

\begin{table}[!ht]
	\centering\small
	\caption{ Prediction tools\cite{1}.\label{tab:1}}
	\begin{tabular*}{\linewidth}{@{\extracolsep{\fill}}*{1}{cccccccccc}}
		\hline
		Tools	&	Methods	&	ACC	&	PRE	&	REC	&	F1	&	MCC	&	AUC	&	AUPRC	&	Time \\
		\hline
		NP-HMMer	&	HMM	&	0.73	&	1.00	&	0.45	&	0.62	&	0.54	&	0.73	&	0.73	&	2.9 \\
		NeuroPP	&	SVM	&	0.84	&	0.82	&	0.87	&	0.84	&	0.68	&	0.84	&	0.78	&	- \\
		NeuroPID	&	Ensemble	&	0.47	&	0.40	&	0.13	&	0.20	&	-0.09	&	0.47	&	0.49	&	152.92 \\
		\hline
	\end{tabular*}
	\begin{tablenotes}
		\footnotesize
		\item This part is footer. ACC: accuracy; PRE: precision; REC: recall; F1: F1-score; MCC: matthews correlation coefficient; AUC: area under the curve; AUPRC: area under precision-recall curve.
	\end{tablenotes}
\end{table}

\textit{Table notes:}
\begin{itemize}
	\item \textit{Tables should be cited in numeric order and placed after the paragraph where it is first cited;}
	\item \textit{The table caption should be placed above the table and labeled sequentially (e.g., Table 1, Table 2);}
	\item \textit{Tables should be provided in editable form like DOC or DOCX format (picture is not allowed);}
	\item \textit{Abbreviations and symbols used in table should be explained in footnote;}
	\item \textit{Explanatory matter should also be placed in footnotes;}
	\item \textit{Non-English words should be avoided;}
	\item \textit{Permission for use of copyrighted materials from other sources, including re-published, adapted, modified, or partial tables from the internet, must be obtained. It is authors' responsibility to acquire the licenses, to follow any citation instruction requested by third-party rights holders, and cover any supplementary charges.}
\end{itemize}

\begin{figure}[!ht]
	\centering
	\includegraphics[width=0.75\textwidth]{figures/Figure1.png}
	\caption{Flowchart of the MediHerb model. (A) Input stage: multi-modal encoders represent the main ingredient of each herb using chemical, structural, physiological, and textual features; (B) Fusion stage: five modalities are integrated via attention and aggregated across herbs in a prescription; (C) Prediction stage: fused features are processed by transformer blocks and a sigmoid layer to produce disease probabilities, optimized with an asymmetric loss for imbalanced multi-label data\cite{2}. SMILES: simplified molecular input line entry system; Bi-LSTM: bidirectional long short-term memory; FC: fully connected; ECFP: extended connectivity fingerprint; MACCS: molecular access system; ERG: extended reduced graph; MHA: multi-head attention.}
	\label{fig:1}
\end{figure}

\textit{Figure notes:}
\begin{itemize}
	\item Figures should be cited in numeric order (e.g., Figure 1, Figure 2) and placed after the paragraph where it is first cited;
	\item Figures can be submitted in format of tiff, psd, AI or jpeg, with resolution of 300-600 dpi;
	\item The figure caption should be positioned below the figure;
	\item Diagrams containing descriptive text (such as flow charts, coordinate diagrams, bar charts, line charts, and scatter plots) should be editable in Word, Excel, or PowerPoint formats. Non-English information should be avoided;
	\item Labels, numbers, letters, arrows, and symbols within figures should be clear, uniform in size, and contrast with the background;
	\item Symbols, arrows, numbers, or letters used to identify parts of the illustrations must be identified and explained in the legend; 
	\item For figures with multiple panels, each panel should be distinctly labeled (A), (B), (C), etc;
	\item Internal scale (magnification) should be explained and the staining method in photomicrographs should be identified; 
	\item Symbols, arrows, numbers, or letters used for identification within illustrations must be clearly defined in the legend;
	\item All non-standard abbreviations should be explained in the legend; 
	\item Authors should pay attention to the protection of patients' rights, such as privacy and portrait, and obtain signed patient consent from authors before using any personal information of patients. The patient's portrait with full characters and his/her real name is not allowed for use; 
	\item Permission for use of copyrighted materials from other sources, including re-published, adapted, modified, or partial figures and images from the internet, must be obtained. It is authors' responsibility to acquire the licenses, to follow any citation instruction requested by third-party rights holders, and cover any supplementary charges.
\end{itemize}
\begin{equation*}
	J=\frac{9}{8}\varepsilon_0\varepsilon_r\mu\frac{E^2}{L}
\end{equation*}

\textit{Equation note:}
\begin{itemize}
	\item \textit{Equations should be provided in editable form (image file format is not allowed).}
\end{itemize}

\section{Dissussion}

The Discussion section should interpret results in the context of existing literature, addressing the study's implications, limitations, and potential mechanisms.

\section{Conclusion}

The Conclusion section should emphasize the study's contribution to the field, suggest future research directions, and highlight practical implications for clinical practice or public health policy.

\textit{Tips:}
\begin{itemize}
	\item \textit{Be clear and concise, avoiding repetition of main text details.}
	\item \textit{Avoid introducing new data or findings.}
	\item \textit{Highlight potential future developments in the field.}
\end{itemize}

\section*{Declarations}

\subsection*{Acknowledgments}

Anyone who contributed towards the article but does not meet \href{http://www.icmje.org/recommendations/browse/roles-and-responsibilities/defining-the-role-of-authors-and-contributors.html}{the criteria} for authorship, including those who provided professional writing services or materials, should be acknowledged. Authors should obtain permission to acknowledge from all those mentioned in the Acknowledgments section. This section is not added if the author does not have anyone to acknowledge.

\subsection*{Authors contribution}

Each author should have contributed significantly to the conception, design, acquisition, analysis, or interpretation of data, or the creation of new software used in the work, or substantively revised the manuscript. Contributions should be indicated using Surname and Initials of Forename. 

For example: 

Single author: 

The author contributed solely to the article.

Two or more authors:

Pal U, Li M: Data analysis and interpretation.

Tian P, Bella F: Article conception and design.

…

\subsection*{Conflicts of interest}

The Conflicts of Interest section should disclose any financial or personal relationships that could potentially bias the study's findings or influence the authors' interpretation. Authors should explicitly state whether they have received funding, honoraria, or fees from organizations that may benefit from the research outcomes, or if they hold any patents or have financial interests related to the study topic. If no conflicts of interest exist, authors should explicitly state ``The authors declare no conflicts of interest." Transparency in disclosing potential conflicts ensures trustworthiness and integrity in biomedical research publications. Some authors may be restricted by confidentiality agreements; in such cases, authors should declare ``All authors declare that they are bound by confidentiality agreements preventing disclosure of conflicts of interest in this work".

\subsubsection*{Ethical approval}

Research involving human subjects, human materials, human data, and animals must adhere to the principles outlined in the \href{https://www.wma.net/policies-post/wma-declaration-of-helsinki/}{Declaration of Helsinki} and state that the study protocol was reviewed and approved by an appropriate ethics committee or institutional review board (IRB), including the name of the board and the approval number if applicable. 

\subsection*{Consent to participate}

This section should mention that consent to participate was obtained from all participants or their legal representatives, ensuring that participants were fully informed about the study's purpose, procedures, risks, and benefits before consenting to participate. 

If this issue is not applicable to the manuscript, please indicate ``Not applicable".

\subsection*{Consent for publication}

Written informed consent for the publication of any identifying information (individual details, images, or videos) or personal data included in the manuscript, should be obtained from all participants, or their legal guardians. In cases where the individual has passed away, consent must be obtained from their next of kin. This section ensures that participants are aware of how their data will be used and agree to its publication.

If this issue is not applicable to the manuscript, please indicate ``Not applicable".

\subsection*{Availability of data and materials}

Authors should declare where the data supporting their findings can be found. Data can be deposited into data repositories or published as supplementary information in the journal. Authors who cannot share their data should state that the data will not be shared and explain it. 

If a manuscript does not involve such issue, please state ``Not applicable." in this section.


\subsection*{Funding}

In this section, authors should acknowledge all financial support received for the study. This includes grants, fellowships, and any other funding sources. It should specify the names of the funding agencies, the grant numbers, and any relevant project titles. If no funding was received, this should be stated ``None" in this section.

\subsection*{Copyright}

© The Author(s) Year.

\begin{thebibliography}{00}
	\bibitem{1} Xu W, Wang L, Wang M, Jiang J, Xue Z, Wang Y. A comprehensive review on neuropeptides: databases and computational tools. Comput Biomed. 2025;1:202402. [DOI:10.70401/cbm.2025.0001]
	
	\bibitem{2} Liu X, Chen F, Pan J, Ai C, Guo F, Tang J. MediHerb: A multi-modal enhanced framework for disease inference via herbal knowledge. Comput Biomed. 2025;1(1):202509. [DOI:10.70401/cbm.2025.0002]
\end{thebibliography}

\section*{Publisher's Note}

Science Exploration remains a neutral stance on jurisdictional claims in published maps and institutional affiliations. The views expressed in this article are solely those of the author(s) and do not reflect the opinions of the Editors or the publisher.

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